Drugs that accelerate metabolism

The latest research relating Таблетки, ускоряющие метаболизм в организме

Scientists are conducting final testing of the newest means to combat obesity – these are injections that turn “bad” white fat into “quality” brown.

In the spring many people remember that it’s time to get rid of excess weight and monitor your health. Start the recovery of the body and lose weight is with improving metabolism.


To simplify the perception of information, this instruction for use of the drug “Tablets that accelerate metabolism in the body” translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.


Many people set themselves the task of speeding up the exchangesubstances in the body. Most often, the need for this arises when you need to lose weight, but it is sometimes required in certain diseases (for example, in violation of the functions of the thyroid gland). One way or another, the problem with slow metabolism needs to be approached in a comprehensive way, changing the way of life and getting rid of diseases, but there are also separate ways that help to change metabolism.

How can you speed up the metabolism through nutrition?

The metabolism is directly related to nutrition and hormones. But if the latter we can not always adjust, then change the diet in our power.

Products that accelerate the metabolism:

  1. Condiments. It is known that dishes flavored with pepper,accelerate metabolism by 25%. This is due to capsaicin, which is contained in it in large quantities. This substance prevents the occurrence of malignant formations, according to scientists from Nottingham University. Another seasoning, which speeds up the metabolism – cinnamon. Its impact on metabolism is estimated at 10%, so if you add pepper and cinnamon to any dish, it will promote metabolism. Ginger and curry are also useful for metabolism.
  2. Fruit. To accelerate metabolism, it is best to beginBreakfast with citrus fruits: this will help the intestines work, and will also equip the body with vitamins. Other fruits also have a beneficial effect on metabolism, but not as much as lemon, orange, mandarin or grapefruit.
  3. Dairy. Due to the high content of calcium, products such as kefir, cottage cheese, milk and sour cream accelerate metabolism.
  4. Cooked meat. Protein – an integral part of metabolism, so that it is not violated, the diet should be cooked beef or pork.
  5. Nuts. They contain a lot of polyunsaturated fats – irreplaceable links of metabolism. It is enough to eat 100 g of hazelnuts, almonds, cashews (to choose from) to speed up the metabolic processes.

A diet that accelerates the metabolism

The main rule of the diet for the acceleration of metabolism- eat often, but in small quantities. The digestive tract should be constantly in work: so, after breakfast, after an hour you can eat an apple, and after two to eat nuts, after a while to take a slice of cheese, etc. Such a diet contributes to good digestion of foods, as well as the acceleration of metabolism through the continuous operation of the gastrointestinal tract.

Drugs that accelerate metabolism

If the goal of accelerating metabolism is weight loss,Then the use of medications is highly undesirable: the fact is that they affect the body, and, in fact, are effective, but at the same time have a lot of side effects.

Drugs that accelerate metabolism:

  1. Strumel T – Homeopathic drug, which is prescribed for people with hypothyroidism.
  2. L-thyroxine – a hormonal drug, which is prescribed to those in whomWho have low T4. The endocrine system is closely related to the pituitary and hypothalamus, which regulate the amount of thyroid hormones produced, which in turn affect the metabolism. If there are a lot of hormones, then the metabolism speeds up, so L-thyroxine will help to lose weight, but in addition can knock down the menstrual cycle (the ratio of estrogen and progesterone), and also teach the thyroid gland to inactivity (means that the drug will have to take more than one year).

Vitamins that accelerate metabolism

Such vitamins as: D, B6, and C accelerate metabolic processes, but their excess amount is also harmful to health. It is best to accelerate metabolism with products, because there are natural vitamins.

Additional funds that accelerate metabolism

Different drinks can also speed up the metabolic processes, so they can be included in your daily diet.

  1. Decoctions. There are herbs that accelerate the metabolism: chamomile, celery, dandelion, lemon balm, a turn – they can be consumed instead of tea or coffee.
  2. Coffee and tea. Natural coffee speeds up the metabolism, butdo not cause a tachycardia, it is best to drink it no more than 1 cup a day. Also, the acceleration of metabolism affects green tea with jasmine – it has a weak diuretic effect and contains caffeine.
  3. Alcohol. The only alcoholic beverage thataccelerates the metabolism – beer. However, it is done by yeast (not suitable for those who want to lose weight) and can cause addiction, so it should not be used for medical purposes: there are too many more useful ways around to speed up metabolism to resort to beer.


Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos “stranger” and biotic “related to living beings”) is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism’s normal biochemistry, such any drug or poison. These pathways are a form of biotransformation present in all major groups of organisms, and are considered to be of ancient origin. These reactions often act to detoxify poisonous compounds (although in some cases the intermediates in xenobiotic metabolism can themselves cause toxic effects). The study of drug metabolism is called pharmacokinetics.

The metabolism of pharmaceutical drugs is an important aspect of pharmacology and medicine. For example, the rate of metabolism determines the duration and intensity of a drug’s pharmacologic action. Drug metabolism also affects multidrug resistance in infectious diseases and in chemotherapy for cancer, and the actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a common reason for hazardous drug interactions. These pathways are also important in environmental science, with the xenobiotic metabolism of microorganisms determining whether a pollutant will be broken down during bioremediation, or persist in the environment. The enzymes of xenobiotic metabolism, particularly the glutathione S-transferases are also important in agriculture, since they may produce resistance to pesticides and herbicides.

Drug metabolism is divided into three phases. In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes such as glutathione S-transferases. Finally, in phase III, the conjugated xenobiotics may be further processed, before being recognised by efflux transporters and pumped out of cells. Drug metabolism often converts lipophilic compounds into hydrophilic products that are more readily excreted.

Permeability barriers and detoxification

The exact compounds an organism is exposed to will be largely unpredictable, and may differ widely over time; these are major characteristics of xenobiotic toxic stress. The major challenge faced by xenobiotic detoxification systems is that they must be able to remove the almost-limitless number of xenobiotic compounds from the complex mixture of chemicals involved in normal metabolism. The solution that has evolved to address this problem is an elegant combination of physical barriers and low-specificity enzymatic systems.

All organisms use cell membranes as hydrophobic permeability barriers to control access to their internal environment. Polar compounds cannot diffuse across these cell membranes, and the uptake of useful molecules is mediated through transport proteins that specifically select substrates from the extracellular mixture. This selective uptake means that most hydrophilic molecules cannot enter cells, since they are not recognised by any specific transporters. In contrast, the diffusion of hydrophobic compounds across these barriers cannot be controlled, and organisms, therefore, cannot exclude lipid-soluble xenobiotics using membrane barriers.

However, the existence of a permeability barrier means that organisms were able to evolve detoxification systems that exploit the hydrophobicity common to membrane-permeable xenobiotics. These systems therefore solve the specificity problem by possessing such broad substrate specificities that they metabolise almost any non-polar compound. Useful metabolites are excluded since they are polar, and in general contain one or more charged groups.

The detoxification of the reactive by-products of normal metabolism cannot be achieved by the systems outlined above, because these species are derived from normal cellular constituents and usually share their polar characteristics. However, since these compounds are few in number, specific enzymes can recognize and remove them. Examples of these specific detoxification systems are the glyoxalase system, which removes the reactive aldehyde methylglyoxal, and the various antioxidant systems that eliminate reactive oxygen species.

Phases of detoxification

Phases I and II of the metabolism of a lipophilic xenobiotic.

The metabolism of xenobiotics is often divided into three phases:- modification, conjugation, and excretion. These reactions act in concert to detoxify xenobiotics and remove them from cells.

Phase I – modification

In phase I, a variety of enzymes act to introduce reactive and polar groups into their substrates. One of the most common modifications is hydroxylation catalysed by the cytochrome P-450-dependent mixed-function oxidase system. These enzyme complexes act to incorporate an atom of oxygen into nonactivated hydrocarbons, which can result in either the introduction of hydroxyl groups or N-, O- and S-dealkylation of substrates. The reaction mechanism of the P-450 oxidases proceeds through the reduction of cytochrome-bound oxygen and the generation of a highly-reactive oxyferryl species, according to the following scheme:

O2 + NADPH + H+ + RH → NADP+ + H2O + ROH

Phase I reactions (also termed nonsynthetic reactions) may occur by oxidation, reduction, hydrolysis, cyclization, decyclization, and addition of oxygen or removal of hydrogen, carried out by mixed function oxidases, often in the liver. These oxidative reactions typically involve a cytochrome P450 monooxygenase (often abbreviated CYP), NADPH and oxygen. The classes of pharmaceutical drugs that utilize this method for their metabolism include phenothiazines, paracetamol, and steroids. If the metabolites of phase I reactions are sufficiently polar, they may be readily excreted at this point. However, many phase I products are not eliminated rapidly and undergo a subsequent reaction in which an endogenous substrate combines with the newly incorporated functional group to form a highly polar conjugate.

A common Phase I oxidation involves conversion of a C-H bond to a C-OH. This reaction sometimes converts a pharmacologically inactive compound (a prodrug) to a pharmacologically active one. By the same token, Phase I can turn a nontoxic molecule into a poisonous one (toxification). Simple hydrolysis in the stomach is normally an innocuous reaction, however there are exceptions. For example, phase I metabolism converts acetonitrile to HOCH2CN, which rapidly dissociates into formaldehyde and hydrogen cyanide, both of which can be toxic.

Phase I metabolism of drug candidates can be simulated in the laboratory using non-enzyme catalysts. This example of a biomimetic reaction tends to give products that often contains the Phase I metabolites. As an example, the major metabolite of the pharmaceutical trimebutine, desmethyltrimebutine (nor-trimebutine), can be efficiently produced by in vitro oxidation of the commercially available drug. Hydroxylation of an N-methyl group leads to expulsion of a molecule of formaldehyde, while oxidation of the O-methyl groups takes place to a lesser extent.


  • Cytochrome P450 monooxygenase system
  • Flavin-containing monooxygenase system
  • Alcohol dehydrogenase and aldehyde dehydrogenase
  • Monoamine oxidase
  • Co-oxidation by peroxidases


  • NADPH-cytochrome P450 reductase

Cytochrome P450 reductase, also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase, POR, CPR, CYPOR, is a membrane-bound enzyme required for electron transfer to cytochrome P450 in the microsome of the eukaryotic cell from a FAD- and FMN-containing enzyme NADPH:cytochrome P450 reductase The general scheme of electron flow in the POR/P450 system is: NADPH → FAD → FMN → P450 → O2

  • Reduced (ferrous) cytochrome P450

During reduction reactions, a chemical can enter futile cycling, in which it gains a free-radical electron, then promptly loses it to oxygen (to form a superoxide anion).


  • Esterases and amidase
  • Epoxide hydrolase

Phase II – conjugation

In subsequent phase II reactions, these activated xenobiotic metabolites are conjugated with charged species such as glutathione (GSH), sulfate, glycine, or glucuronic acid. Sites on drugs where conjugation reactions occur include carboxyl (-COOH), hydroxyl (-OH), amino (NH2), and sulfhydryl (-SH) groups. Products of conjugation reactions have increased molecular weight and tend to be less active than their substrates, unlike Phase I reactions which often produce active metabolites. The addition of large anionic groups (such as GSH) detoxifies reactive electrophiles and produces more polar metabolites that cannot diffuse across membranes, and may, therefore, be actively transported.

These reactions are catalysed by a large group of broad-specificity transferases, which in combination can metabolise almost any hydrophobic compound that contains nucleophilic or electrophilic groups. One of the most important classes of this group is that of the glutathione S-transferases (GSTs).

methylation methyltransferase S-adenosyl-L-methionine liver, kidney, lung, CNS
sulphation sulfotransferases 3′-phosphoadenosine-5′-phosphosulfate liver, kidney, intestine
  • N-acetyltransferases
  • bile acid-CoA:amino acid N-acyltransferases
acetyl coenzyme A liver, lung, spleen, gastric mucosa, RBCs, lymphocytes
glucuronidation UDP-glucuronosyltransferases UDP-glucuronic acid liver, kidney, intestine, lung, skin, prostate, brain
glutathione conjugation glutathione S-transferases glutathione liver, kidney
glycine conjugation Two step process:

  1. XM-ligase (forms a xenobiotic acyl-CoA)
  2. Glycine N-acyltransferase (forms the glycine conjugate)
glycine liver, kidney

Phase III – further modification and excretion

After phase II reactions, the xenobiotic conjugates may be further metabolised. A common example is the processing of glutathione conjugates to acetylcysteine (mercapturic acid) conjugates. Here, the γ-glutamate and glycine residues in the glutathione molecule are removed by Gamma-glutamyl transpeptidase and dipeptidases. In the final step, the cystine residue in the conjugate is acetylated.

Conjugates and their metabolites can be excreted from cells in phase III of their metabolism, with the anionic groups acting as affinity tags for a variety of membrane transporters of the multidrug resistance protein (MRP) family. These proteins are members of the family of ATP-binding cassette transporters and can catalyse the ATP-dependent transport of a huge variety of hydrophobic anions, and thus act to remove phase II products to the extracellular medium, where they may be further metabolised or excreted.

Endogenous toxins

The detoxification of endogenous reactive metabolites such as peroxides and reactive aldehydes often cannot be achieved by the system described above. This is the result of these species’ being derived from normal cellular constituents and usually sharing their polar characteristics. However, since these compounds are few in number, it is possible for enzymatic systems to utilize specific molecular recognition to recognize and remove them. The similarity of these molecules to useful metabolites therefore means that different detoxification enzymes are usually required for the metabolism of each group of endogenous toxins. Examples of these specific detoxification systems are the glyoxalase system, which acts to dispose of the reactive aldehyde methylglyoxal, and the various antioxidant systems that remove reactive oxygen species.


Quantitatively, the smooth endoplasmic reticulum of the liver cell is the principal organ of drug metabolism, although every biological tissue has some ability to metabolize drugs. Factors responsible for the liver’s contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs. If a drug is taken into the GI tract, where it enters hepatic circulation through the portal vein, it becomes well-metabolized and is said to show the first pass effect.

Other sites of drug metabolism include epithelial cells of the gastrointestinal tract, lungs, kidneys, and the skin. These sites are usually responsible for localized toxicity reactions.

Factors that affect drug metabolism

The duration and intensity of pharmacological action of most lipophilic drugs are determined by the rate they are metabolized to inactive products. The Cytochrome P450 monooxygenase system is the most important pathway in this regard. In general, anything that increases the rate of metabolism (e.g., enzyme induction) of a pharmacologically active metabolite will decrease the duration and intensity of the drug action. The opposite is also true (e.g., enzyme inhibition). However, in cases where an enzyme is responsible for metabolizing a pro-drug into a drug, enzyme induction can speed up this conversion and increase drug levels, potentially causing toxicity.

Various physiological and pathological factors can also affect drug metabolism. Physiological factors that can influence drug metabolism include age, individual variation (e.g., pharmacogenetics), enterohepatic circulation, nutrition, intestinal flora, or sex differences.

In general, drugs are metabolized more slowly in fetal, neonatal and elderly humans and animals than in adults.

Genetic variation (polymorphism) accounts for some of the variability in the effect of drugs. With N-acetyltransferases (involved in Phase II reactions), individual variation creates a group of people who acetylate slowly (slow acetylators) and those who acetylate quickly, split roughly 50:50 in the population of Canada. This variation may have dramatic consequences, as the slow acetylators are more prone to dose-dependent toxicity.

Cytochrome P450 monooxygenase system enzymes can also vary across individuals, with deficiencies occurring in 1 – 30% of people, depending on their ethnic background.

Dose, frequency, route of administration, tissue distribution and protein binding of the drug affect its metabolism.

Pathological factors can also influence drug metabolism, including liver, kidney, or heart diseases.

In silico modelling and simulation methods allow drug metabolism to be predicted in virtual patient populations prior to performing clinical studies in human subjects. This can be used to identify individuals most at risk from adverse reaction.


Studies on how people transform the substances that they ingest began in the mid-nineteenth century, with chemists discovering that organic chemicals such as benzaldehyde could be oxidized and conjugated to amino acids in the human body. During the remainder of the nineteenth century, several other basic detoxification reactions were discovered, such as methylation, acetylation, and sulfonation.

In the early twentieth century, work moved on to the investigation of the enzymes and pathways that were responsible for the production of these metabolites. This field became defined as a separate area of study with the publication by Richard Williams of the book Detoxication mechanisms in 1947. This modern biochemical research resulted in the identification of glutathione S-transferases in 1961, followed by the discovery of cytochrome P450s in 1962, and the realization of their central role in xenobiotic metabolism in 1963.

See also


  1. ^ a b c Jakoby WB, Ziegler DM (December 1990). “The enzymes of detoxication”. J. Biol. Chem. (34): 20715–8. PMID 2249981. 
  2. ^ Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (September 2003). “Impact of drug transporter studies on drug discovery and development”. Pharmacol. Rev. (3): 425–61. doi:10.1124/pr.55.3.1. PMID 12869659. 
  3. ^ Thornalley PJ (July 1990). “The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life”. Biochem. J. (1): 1–11. PMC 1131522 . PMID 2198020. 
  4. ^ Sies H (March 1997). “Oxidative stress: oxidants and antioxidants” (PDF). Exp. Physiol. (2): 291–5. doi:10.1113/expphysiol.1997.sp004024. PMID 9129943. 
  5. ^ Guengerich FP (June 2001). “Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity”. Chem. Res. Toxicol. (6): 611–50. doi:10.1021/tx0002583. PMID 11409933. 
  6. ^ Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG (March 2000). “The catalytic pathway of cytochrome p450cam at atomic resolution”. Science. (5458): 1615–22. Bibcode:2000Sci…287.1615S. doi:10.1126/science.287.5458.1615. PMID 10698731. 
  7. ^ “Acetonitrile (EHC 154, 1993)”. www.inchem.org. Retrieved 2017-05-03. 
  8. ^ Akagah B, Lormier AT, Fournet A, Figadère B (December 2008). “Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates”. Org. Biomol. Chem. (24): 4494–7. doi:10.1039/b815963g. PMID 19039354. 
  9. ^ a b c d e Liston HL, Markowitz JS, DeVane CL (October 2001). “Drug glucuronidation in clinical psychopharmacology”. J Clin Psychopharmacol. (5): 500–15. doi:10.1097/00004714-200110000-00008. PMID 11593076. 
  10. ^ Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA (September 2013). “Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation”. Expert Opinion on Drug Metabolism & Toxicology. (9): 1139–1153. doi:10.1517/17425255.2013.796929. PMID 23650932. Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C., is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A (CoASH). However, because of the small number of pharmaceutical drugs that are conjugated to glycine, the pathway has not yet been characterized in detail. Here, we review the causes and possible consequences of interindividual variation in the glycine conjugation pathway. …
    Figure 1. Glycine conjugation of benzoic acid. The glycine conjugation pathway consists of two steps. First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. … The benzoyl-CoA is then conjugated to glycine by GLYAT to form hippuric acid, releasing CoASH. In addition to the factors listed in the boxes, the levels of ATP, CoASH, and glycine may influence the overall rate of the glycine conjugation pathway.
  11. ^ Boyland E, Chasseaud LF (1969). “The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis”. Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology – and Related Areas of Molecular Biology. : 173–219. doi:10.1002/9780470122778.ch5. ISBN 9780470122778. PMID 4892500. 
  12. ^ Homolya L, Váradi A, Sarkadi B (2003). “Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate”. BioFactors. (1–4): 103–14. doi:10.1002/biof.5520170111. PMID 12897433. 
  13. ^ König J, Nies AT, Cui Y, Leier I, Keppler D (December 1999). “Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance”. Biochim. Biophys. Acta. (2): 377–94. doi:10.1016/S0005-2736(99)00169-8. PMID 10581368. 
  14. ^ Commandeur JN, Stijntjes GJ, Vermeulen NP (June 1995). “Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics”. Pharmacol. Rev. (2): 271–330. PMID 7568330. 
  15. ^ Rostami-Hodjegan A, Tucker GT (February 2007). “Simulation and prediction of in vivo drug metabolism in human populations from in vitro data”. Nat Rev Drug Discov. (2): 140–8. doi:10.1038/nrd2173. PMID 17268485. 
  16. ^ Murphy PJ (June 2001). “Xenobiotic metabolism: a look from the past to the future”. Drug Metab. Dispos. (6): 779–80. PMID 11353742. 
  17. ^ Neuberger A, Smith RL (1983). “Richard Tecwyn Williams: the man, his work, his impact”. Drug Metab. Rev. (3): 559–607. doi:10.3109/03602538308991399. PMID 6347595. 
  18. ^ Booth J, Boyland E, Sims P (June 1961). “An enzyme from rat liver catalysing conjugations with glutathione”. Biochem. J. (3): 516–24. PMC 1205680 . PMID 16748905. 
  19. ^ Omura T, Sato R (April 1962). “A new cytochrome in liver microsomes”. J. Biol. Chem. : 1375–6. PMID 14482007. 
  20. ^ Estabrook RW (December 2003). “A passion for P450s (remembrances of the early history of research on cytochrome P450)”. Drug Metab. Dispos. (12): 1461–73. doi:10.1124/dmd.31.12.1461. PMID 14625342. 
  21. ^ Estabrook RW, Cooper DY, Rosenthal O (1963). “The light reversible carbon monoxide inhibition of steroid C-21 hydroxylase system in adrenal cortex”. Biochem Z. : 741–55. PMID 14087340. 

Further reading

  • Parvez H, Reiss C (2001). Molecular Responses to Xenobiotics. Elsevier. ISBN 0-345-42277-5. 
  • Ioannides C (2001). Enzyme Systems That Metabolise Drugs and Other Xenobiotics. John Wiley and Sons. ISBN 0-471-89466-4. 
  • Richardson M (1996). Environmental Xenobiotics. Taylor & Francis Ltd. ISBN 0-7484-0399-X. 
  • Ioannides C (1996). Cytochromes P450: Metabolic and Toxicological Aspects. CRC Press Inc. ISBN 0-8493-9224-1. 
  • Awasthi YC (2006). Toxicology of Glutathionine S-transferses. CRC Press Inc. ISBN 0-8493-2983-3. 

External links

  • Databases
    • Drug metabolism database
    • Directory of P450-containing Systems
    • University of Minnesota Biocatalysis/Biodegradation Database
    • SPORCalc
  • Drug metabolism
    • Small Molecule Drug Metabolism
    • Drug metabolism portal
  • Microbial biodegradation
    • Microbial Biodegradation, Bioremediation and Biotransformation
  • History
    • History of Xenobiotic Metabolism at the Wayback Machine (archived July 13, 2007)


That just does not make women in his quest to lose weight. Exhausting exercise, countless diets – all aimed at achieving irresistible. I want to be slim, confident, but not always enough strength and patience to fight this battle with unwanted pounds. Many people wish to reduce weight, but often laziness does not bring the body in order. Here come to the aid of the drugs for weight loss. What is easier – took the pill, and the weight is reduced. Let’s understand how these drugs work and are they always effective.

Types of medications for weight loss

The means by which the process of weight loss, very much. They act on the body and solve different problems. Cheap diet pills and Supplements with cosmic price, teas and vitamins – all agitating for a rapid and effective reduction of body weight. But many drugs have contraindications, side effects and are harmful to the health. Before you start using them, consult a dietitian or endocrinologist.

Drugs for quick weight loss is produced in the form of tablets, capsules. Very popular biologically active substances, homeopathic medicines, teas for slimming.

The main tasks that decide such drugs:

  • decrease feelings of hunger;
  • the excretion of toxins;
  • the improvement of metabolism;
  • fat burning;
  • loss of appetite.

The drug «Aqualis» is not a tool for weight loss, but it produced cosmetic injections, which destroy the extra fat. Injections replace surgery liposuction. Make them in a problem locally – it can be a double chin, thigh, abdomen. A strong active ingredient that destroys fat cells. The operation is performed only in a beauty salon.


Excellent results for weight loss is the use of tablets. Among them, the domestic drugs and Asian funds. A popular Thai, Chinese tablets. Domestic product «Ideal» prevents the absorption of fat, but good results are obtained only in Union with a low-calorie diet. Using pills «meridia» allows three times to reduce the amount of food eaten. The drug «Venlaxor» because of contraindications taking strictly on doctor’s prescription.


Effective pills for fat burning – «Thai bear». Produced from herbal remedies, they improve metabolism, reduce appetite, eliminate toxins. According to the instructions they are 28 days. Depending on the set, during this time, the weight is reduced from 8 to 14 pounds. The use of these drugs has contraindications:

  • pregnancy;
  • high blood pressure;
  • heart disease;
  • the age of 18, older than 65 years.


The rating of the slimming from China headed by the drug «Bomb». The course is designed to month. Pills speed up the metabolism, burning fat. With their help, decreased appetite, cleansing of the body occurs. Good results are obtained by using drug «Bilit». The Chinese tablets «Cinzio» includes plants and fruits, which not only break down fat but also tighten the skin. Nutritionists suggest that you be wary to take these funds because of possible allergic reactions to unfamiliar plants.

Effective weight-loss aid in the pharmacy

Safe drugs for weight loss sold in pharmacies. Here you can find an inexpensive and harmless pill. «MCC» – microcrystalline cellulose, which cleanses the intestines, removes toxins, promotes rapid saturation. Effective Supplements for weight loss «Lida», «Bilit», containing natural herbs, help to reduce weight. Here you can buy product «XLS», normalizing metabolism, teas for slimming. Protein shakes for quick saturation, blockers of fat absorption, capsules-fat burners – it’s all there on the shelves of pharmacies.

Slimming capsule

Opens the list of capsules for weight loss «Xenical». This drug prevents the absorption of fat that enter the stomach with food. He immediately excreted from the body during defecation. Popular drugs in capsules:

  • «Retuxin» – depresses the appetite.
  • «Bilit» – burns fat, improves metabolism.
  • «Lindaxa» – causes a feeling of fullness.
  • «GL» has been working at the center of saturation in the brain.
  • «Ayurslim» – prevents the accumulation of fat.

Drugs that accelerate the metabolism

If a person has a good metabolism, then all that he eats are burnt off. Excess fat is not deposited in the body. There are drugs to reduce the weight acting on the acceleration of metabolism. They not only reduce appetite but also cause the body to waste more energy. Are drugs: «reduxing», «Glycolax», «L-thyroxine». Men use to accelerate metabolism and increase muscle mass «Anavar», «Anadrol». Women these drugs is contraindicated because of the possibility of hormone deficiency. Safe drug «Lecithin».


These drugs to reduce appetite act on the centre of saturation, located in the brain. Due to this, a person reduces the amount of food eaten. Saturation occurs very quickly. Drugs help improve metabolism. Unfortunately, there are many contraindications to the use. Better if you get them prescribed by a doctor. Modern drugs-anorectics:

  • «Retuxin»;
  • «Lindaxa»;
  • «Deestress»;
  • «Dexfenfluramine»;
  • «Gold line international».


The use of dietary Supplements (biologically active additives) is very popular. It reduces appetite and eliminate toxins. With their help burn fat, regulates the metabolism. Popular drugs «Phytomucil», «Ideal figure», «Turboslim». They all behave differently. What is Turboslim the most effective? If you choose from a range of these drugs: «day», «night», «cream», «coffee», «tea», they all work differently. Best produces the action of «Turboslim-day», accelerating the metabolism.

Vitamins for weight loss

Vitamins are not sources for active slimming. They need to support the body during dieting. Because of the deficiency impossible the correct operation of the systems of the body, happen it crashing. Yet it is worth noting the role of vitamins and minerals:

  • B4 – accelerates the breakdown of fats;
  • B5 – participates in the metabolism;
  • B2, B3, B6 – responsible for the thyroid gland;
  • B12 – improves the assimilation of fats;
  • – Helps with burning fat;
  • D – saturates;
  • Chromium is involved in fat metabolism;
  • Zinc – regulates appetite;
  • Calcium helps to get rid of fat.

Drugs chromium

Supplements for weight loss that contain chromium, control fat metabolism, for example, «Allicor-chrome». It even reduces the feeling of hunger, stabilize your glucose levels. Inexpensive diet pills «chromium Picolinate» are sold in pharmacies without prescription, chromium is contained in many vitamin complexes. It exerts its effects on the body:

  • normalizes carbohydrate metabolism;
  • helps to produce insulin;
  • reduces appetite;
  • involved in fat metabolism;
  • stabilizes the sugar level;
  • normalizes cholesterol.

The names of homeopathic medicines

There are several reasons for weight gain: metabolic disorders, stress, uncontrolled appetite. It is better if the drugs for weight loss that really helps, will assign you a doctor. He would find out the reason and prescribe homeopathic medicines narrow spectrum of activity:

  • Muffle hunger «Ignacy», «Anacardium».
  • Remove excess fluid «Sepia», «sulphur».
  • Acting laxative «Lycopodium», «Taraksakum».
  • Eliminates the craving for sweets «Argentum nitricum»
  • Controls appetite «Calcarea Carbonica».

Slimming tea

These tools to maintain a healthy weight are very popular. The effects of slimming teas aimed at improving the metabolism, the breakdown of fats. Often they have a pronounced diuretic and laxative effect. Slimming tea «Stevia» a natural sweetener composition. Popular teas for weight loss: «Flying swallow» and «Monastic tea». Brew, drink a glass before bedtime. As a result of the application of:

  • decreases the layer of fat;
  • eliminates waste products, toxins;
  • works best the intestines;
  • is regulated by cholesterol;
  • decreases weight.

Video: what tablets to drink for weight loss

If you have any doubt that the drugs for quick weight loss really help? Watch the video and you’ll find the answers to their questions. You will learn what processes in the body losing weight when you drink dietary supplements, teas and medications. How long does the effect of weight loss and what you need to do to regulate your weight.

Feedback on the results of the application of

Eugene, 25 years: Gained weight, because I can’t live without sweets. Girlfriend advised to take «chromium Picolinate». Without any problems bought in the pharmacy, take 10 drops morning and evening. After a week of sweet didn’t feel hungry at all, but there was a desire to move. Started going to the gym and a month lost 5 pounds. I recommend the sweet tooth!

Tatyana, 45 years: I was diagnosed with obesity, named «xenical» for the treatment. Warned that it is better to take it whenever don’t have anywhere to go. Why do so – understand, when began to drink. I was in the toilet and I suffer from loose stools, and fat – so the fat derived from the body. Lost weight over the month by 5 pounds, but would advise it if you are prescribed by a doctor.

Barbara, 32 years: For me the most effective way to lose weight – pills «meridia» advised a friend. I have been three times smaller – I lost my appetite. But there was a lot of energy. I started going to the gym. If I previously have engaged in 40 minutes, now an hour and a half, with ease. For a month she lost 4 kgs. Highly recommend!


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